Sen. Edward M. Kennedy (D-Massachusetts), drove a car off a bridge on Massachusetts' Chappaquiddick Island in 1969 after a party. The accident killed aide Mary Jo Kopechne, and controversy over the incident effectively ended the Massachusetts senator's presidential aspirations.
His son Edward Jr. had his right leg amputated in 1973 because of cancer; his son Patrick, now a congressman, sought treatment for cocaine addiction as a teen-ager in 1986.
His nephew, William Kennedy Smith, was accused of rape in 1991 at the family estate in Palm Beach, Florida. He was acquitted.